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Exploring the Versatility of Lipid Nanoparticles in Drug Discovery

February 21, 2024

Lipid nanoparticles (LNPs) have emerged as a compelling drug delivery system, offering significant advantages. Today, we'll delve into what makes LNPs so intriguing and explore why they are gaining traction in the pharmaceutical industry.

Advantages of Lipid Nanoparticles:

  1. Targeted Delivery: Surface motifs allow for targeting specific cells and with this targeting capability you can reduce off-targeting effects so there'll be less side effects to your drug and less drug would be needed.
  2. Great Half-Life: Oftentimes the nanoparticles will have a polyethylene glycol (PEG) serface modification which will allow for immune cell evasion.
  3. Payload Versatility: LNPs are able to carry multiple types of payload, including mRNA which often undergoes degradation in the body. Nanoparticles can protect this cargo from degradation, allowing for a therapeutic that would usually be challenging to use.
  4. Enhanced Cell Uptake: They have improved cell uptake, and with that you can control when the drug is released so you can allow the nanoparticle to be uptaken by the cell and then release the cargo once it's in the cell

Moreover, the endorsement of LNPs by the FDA is exemplified by the successful deployment of COVID-19 vaccines developed by Moderna and BioNTech/Pfizer.

LNP Experimental Workflow Captured in ELN:

  • LNP Components: LNPs are composed of a lipid mix. Most commonly is nucleic acid payload. The lipid mix can include an ionizable lipid, phospholipid, helper lipid, and stabilizer lipid. Several include cholesterol, or a modified cholesterol, but doesn't necessarily have to include all those.
  • Preparation Methods: LNPs are very modular and so they can be mixed, matched, and modified. You can have the same components but adjust how the formulation is made and it’ll result in a very different nanoparticle that may have different characteristics that you're looking for. You could adjust the size, the surface potential, any motifs on the surface of the nanoparticle, all to try to meet your need and provide a good drug delivery system.

Scilligence ELN Approach:

At Scilligence, our Electronic Laboratory Notebook (ELN) offers comprehensive support for LNP design and development:

  1. Capability to design empty and loaded lipid nanoparticles
  2. Our system offers two distinct calculation approaches and they vary based off of the values that the user would have to enter
  3. Ability to handle multiple ionizable lipids and APIs in the nanoparticle design
  4. Retrieve component information directly from your Scilligence RegMol. Just like with the ADC you can register your components so all of your lipids and your RNA using HELM and being able to pull that into ELN to design your lipid nanoparticle
  5. Ability to register your lipid nanoparticle directly from ELN - Available in Version 7.3
  6. Track assays and stability with our suite of apps (ELN, RegMol, and Inventory) - Available in version 7.3

Here is a short ELN demo showcasing the LNP mole% form:

If you have any inquiries regarding how we can enhance support for your scientific workflows or any of our modules, please don't hesitate to reach out to us at [email protected].

Spring Informatics Workshop (In-Person Event)

April 15, 2024
Catalyst Restaurant

We invite you to join us for an exclusive event at the Catalyst restaurant in Cambridge, MA, for our Spring Informatics Workshop on April 15th, from 10:00 am to 1:00 pm.

At this workshop, we will delve deep into the latest updates on the Scilligence informatics platform, designed to support all drug modalities, including drug conjugates and LNP.

Whether you're a seasoned researcher, scientist, or industry professional, this event is tailored to provide valuable insights and practical knowledge to enhance your workflows.

Here are some highlights you can expect:

  • Updates on the latest features and enhancements in RegMol, our unified entity registration system.
  • Exploration of advanced registration capabilities for various modalities.
  • Partner presentations by industry leaders from Certara and Zifo. 

(Stay tuned for the full agenda!)

Connect with peers, learn from industry experts, and discover how the Scilligence informatics platform can streamline and optimize your research processes.

Space is limited, so secure your spot today by clicking this link or the button below. 

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Intuitive Data Analysis

FOCUS allows users to analyze complex sets of chemistry and biology data interactively, identify lead molecules, visualize gaps in Structure-Activity Relationships (SAR), and accelerate drug discovery.

Data import and Charting

Within FOCUS, users can effortlessly import data from files, expanding the range of data sources you can utilize. Visualize chemical and biological data with chemically-aware charting and graphing tools, gaining a deeper understanding of your research.

Collaboration and Security

Collaborate securely in real-time, share findings, and maintain data integrity with robust security and compliance features. FOCUS ensures data privacy and regulatory compliance, while its adaptable framework allows for quick identification of lead molecules, gaps in SAR, and pathways for accelerating drug discovery and research.

 Seamless Data Integration

FOCUS is fully integrated with the rest of the Scilligence suite, allowing users to centralize chemical structures, biological assays, and experimental results from various sources, enabling easy access and unified analysis. FOCUS effortlessly brings together diverse data types, simplifying data management and facilitating cross-functional collaboration among research teams.

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Focus

Elevate your research with the Scilligence FOCUS module, which provides an intuitive and interactive solution for streamlined chemical and biological data analysis. The FOCUS module utilizes an adaptable framework that helps for quick identification of lead molecules. This allows FOCUS to help accelerate drug discovery by helping research teams to collaborate efficiently and make informed decisions.

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Project life cycle management

PMF is the central planning and control function for project management, defining how a project should be planned, implemented, monitored and closed.

Build and design custom workflows

PMF is an intelligent workflow design engine that provides you with a customizable solution for creating, managing and tracking your company’s business processes.

Make project plan online and track project progress

Project task templates streamline every aspect of planning and executing projects, while changes to the project plan can be controlled and approved by multiple users at any time.

Build enterprise internal knowledge base

Powerful indexing tool to search documents, emails, and notes.

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PMF

The Scilligence Project Management Framework (PMF) empowers organizations to manage workflow and project timeline effectively. It is an easy-to-deploy collaboration platform with crucial security control, cogent document sharing, and powerful data mining technology (structure and biosequence search). PMF will help manage your timeline efficiently and integrate workflow seamlessly (ELN, Registration, Inventory, ERP, Outlook).

Enable Cheminformatics and Bioinformatics in Microsoft Office

Cambridge, MA: Scilligence, a leading innovator of scientific software solutions, is thrilled to unveil HELM technology in TouchMol4Office (TM4O). 

TM4O represents an advancement in the realm of cheminformatics and bioinformatics within the Microsoft Office suite, providing researchers and professionals with a comprehensive platform for interfacing with internal and external databases while working seamlessly in applications like Excel, Word, and PowerPoint.

TM4O empowers users with powerful structure search capabilities, advanced informatics for biologics and conjugates, and now HELM support making it an indispensable tool for professionals working in the fields of chemistry, biology, and pharmaceuticals.

Empowering Chem-Bioinformatics within MS Office
Unleash the potential of MS Office with seamless integration of advanced chem-bioinformatics capabilities. This groundbreaking enhancement opens up a world of possibilities for professionals in the scientific and research communities.

Harnessing Macromolecules through HELM 
Embrace the future of scientific research with MS Office’s built-in support for macromolecules by utilizing HELM. Additionally, you have the option to integrate HELMmonomer.org, unlocking access to exclusive HELM monomer libraries and taking your research to new heights.

Effortless Integration with Back-End Databases
Breakdown data silos and improve your research efficiency with TM4O’s ability to seamlessly connect with back-end databases. Now, you can effortlessly convert CAS numbers and registration IDs into molecular structures from diverse data sources, streamlining your workflow like never before.

With the enablement of HELM in TM4O, Scilligence aims to allow scientists to easily and quickly create complex macromolecules by using an industry-standard notation, making it an indispensable asset for researchers, scientists, and professionals across various industries.

“TouchMol4Office with the enablement of HELM technology will empower scientists to explore a wide variety of therapeutics modalities right inside Microsoft Office applications, a daily staple in research environments”, says Jinbo Lee, PhD, CEO at Scilligence Corporation.

Scilligence ELN Selected by WuXi AppTec for Knowledge Management and Collaboration

  • Boston, June 4, 2014

Scilligence Corporation announces today that WuXi AppTec, a leading global pharmaceutical, biopharmaceutical, and medical device outsourcing company, has licensed Scilligence ELN for knowledge management and collaboration. Scilligence ELN, a cross-platform web-based ELN system, will enable WuXi AppTec to better serve the needs of customers globally. Customers can have real-time access to experimental data and provide instant feedback to Wuxi’s scientists in a secure and productive manner.

About WuXi AppTec
WuXi AppTec is a leading global pharmaceutical, biopharmaceutical, and medical device open-access capability and technology platform company with global operations. WuXi AppTec provides a broad and integrated portfolio of services to help worldwide customers and partners shorten the discovery and development time and lower the cost of drug and medical device R&D through an array of cost-effective and efficient solutions.
http://www.wuxiapptec.com

About Scilligence
Scilligence is a leading innovator of web-based cheminformatics and bioinformatics solutions designed for any device, browser, and platform. Scilligence’s tools enhance the knowledge sharing and productivity of researchers in discovery and development of small molecule and biologic therapeutics.

Informatics Workshop: Data-Driven Discovery from Scilligence

April 21, 2015
MassBio Conference Room, 300 Technology Square, 8th Floor, Cambridge, MA

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Share your knowledge across the world

Our innovation is driven by the idea that the best solutions come from shared experiences. We’ve built a tool that makes it easy to share knowledge and resources with colleagues globally.

Collect and process research efficiently

We understand that it can be difficult to wrangle all of the data you need to make industry-changing discoveries. Our ELN is a flexible web platform that allows you to easily find and organize unstructured data.

FAIR data principles

Our advanced search and indexing capabilities allow researchers to quickly search and filter through unstructured data. Seamlessly search by text, substructure, and biological sequences to find what you’re looking for.

Secure your data

Protect your intellectual property by providing site, account, and project level access management. We offer multi-factor authentication and IP address restriction to ensure only authorized people have access to your projects.