In this blog post, we wanted to walk you through the software design philosophy at Scilligence. We pride ourselves on three “pillars” — client needs, industry trends, and market gaps — as fundamental to our success. Collectively, these pillars help us gain a comprehensive understanding of, our clients, the marketplace, and our competitors. They are inter-related and have helped us to make strategic decisions leading to long-term success.

Client Needs
Understanding client needs is the best way for us to keep pace with your demands and to manage short- and long-term expectations (surrounding the same demands):

• Crucial Feedback: Client needs are what got us started in this space! By listening to your suggestions, problem areas, pain-points, and overall feedback, we gain insights to improve our offerings. Listening to your feedback has helped direct our focus towards improving our products and offerings — this can involve anything from bug fixes, optimizations, to upgrades and entirely new features. It is tremendously helpful to us as it lets us know what to do for you.
• Stronger Relationships: We foster trust and loyalty by listening to our clients to ensure you feel heard and understood. We take the time to listen as we value your business and your input to create a positive and engaging relationship. This leads to better products and services, happier clients, and a more successful business overall.

“A fundamental belief at Scilligence” Tony Yuan, Director of R&D says, “is that we listen to our clients. Why? Because our business would not exist without them. We need them to be successful in every regard.”

Industry Trends
Analyzing industry trends is critical for us to thrive and here's why:

• Informed Decisions: Analyzing industry trends has helped us make data-driven choices. We apply this principle to everything from product development to marketing strategies. Perhaps there is a rising demand for a feature that we have not offered before, or a new function that can help make data analysis faster and easier. A good example of this is the Antibody Drug Conjugate form in RegMol (which is our registration software). We built this function from the ground-up with the idea that users will prefer to register the individual components of an ADC and then use them to “piece together” or assemble the ADC itself. Being aware of these trends helps us to not only identify new opportunities but also identify areas for growth and improvement as well.
• Adapting and Evolving: As the scientific community makes new discoveries that increase our understanding of biological processes, there is a need for informatics solutions that accommodate the new paradigm. We are constantly analyzing trends, so we can stay informed about the latest developments and ensure that our offerings are relevant. We innovate and adapt, manage risks, and stay competitive to keep pace with the changing landscape.

Staying updated with industry trends is a critical aspect of our software design philosophy as it empowers us to make informed decisions, plan our roadmap, and be industry pioneers. All of this helps us stay on top of our game and get the best products out to you.

Market Gaps
We see market gap analysis as a vital process for our software design because it helps us uncover hidden opportunities for growth and success. They represent opportunities for us to innovate, optimize existing offerings, or develop new ones to better cater to your unaddressed needs.

• Unmet Needs: Market gaps represent areas where client needs are not being fully satisfied by the current informatics market. By identifying these gaps, we develop innovative solutions so that we can address unmet needs. In some cases, this has led to entirely new product offerings such as the formulation workflow for designing lipid nano-particles (LNPs).
• Building Client Base: By filling a market gap, we have been able to serve a new pool of potential clients who were currently underserved. In fact, this has been the driving philosophy that perfectly blends features and functions across a centralized, unified platform that clients were previously “cobbling together” from disparate options.
• Competitive Advantage: Addressing a market gap also gives us a significant edge over our competition. We were the first ones to build the HELM Web Editor in collaboration with the Pistoia Alliance. We have pioneered this technology that effectively fulfills the unmet need of representing macromolecules. At the same time, we have captured a loyal client base long before our competitors who are only now entering this space.

Analyzing market gaps informs us where to focus our attention and what features and functions to develop and has allowed us to distinguish ourselves from the competition.

In conclusion: Industry Trends + Client Needs + Market Gaps = Solutions that work for you. By bringing these three elements together at Scilligence we have developed a strong understanding of our target market and have positioned ourselves to offer solutions that truly resonate with our clients.

Assay Protocols and Views

• Protocol columns (admin feature): Can use a dictionary list for the items list when using select column type
• In Add Assay Results page: The ability to Hide Blank columns in this page can be added with a configuration
• Protocol columns (admin feature): The Assigned Protocols column has been moved to a child table to improve the usability and space management of this table
• Assay View function change: When using the Download All function to download assay view results to CSV or SDF, the user must click the save button first to save the assay view
• Assay View: removed limitation on upload of more than 1000 entities

Cross-application Integration

• Registration and Inventory database and GUI alignment: Registered entities in RegMol and the corresponding Products, Lots and Containers in Inventory are synchronized.
• Swagger page/API key additions and general improvements
  • Plate Maps list and save
  • Parent check will recognize invalid structures and return a message

UIUX

• Improved messaging:
  • In an integrated system (ELN or Inventory integrated with RegMol) if a user or project does not match in one of the apps, the pop-up message will indicate which app is causing the permission block when pushing entity information
• Improvements to language detection:
  • The system can now recognize an Entity Type if written in Chinese characters
  • Improvements to Chinese and Korean characters display in CSV downloads from the Cart page
• In the RegMol Cart Parent and Batch ID's are now clickable links to the entity page
• General text visualization improvements when using Dark Mode
• Admin Feature: A full-screen option is added to Structure Editor in the Update Structure/Sequence dialog to allow better visualization of larger sequences/structures
• The structure views are harmonized across RegMol for example in the Cart page and Project Portal structure images will display as the same size
• Parent Entities MW column: Improvements to MW display so that the numbers are now right justified
• UI clean up
  • Removed unnecessary icons
  • Replaced grid filters with column sort

Search and Explorer

• Improvements made for:
  • Query speed
  • Standardizing Search types e.g., adding atom level search to Advanced Search

HELM and Enumeration

• Improved messaging for denoting special characters in HELM monomer symbols

Entity Types

ADC/Conjugates

• Streamlined entity forms by removing unnecessary fields
• Bulk upload improvements by aligning Single and Bulk Registration mapping fields
• Informational messaging improvements for ADC component connection registration process
• Provided capability to register No-Structure ADCs. Three use cases:
  • No Structure at all
  • No Sequence Antibody
  • No Payload Structure

Protein

• Translate and display the amino acid sequence of a highlighted coding region of DNA entry

Plasmid

• Added the ability to update a parent sequence using the Admin> Data Management> Update Structure/Sequence

Registration

• Added more size unit options for containers
• Parent Explorer page: Ability to add Custom Column filtering (with configuration)
• Registration Form UIUX: For an existing compound having an External ID, the External ID field is empty on the registration form when creating a new batch
• Registration UIUX improvement: When sorting by Parent under the Project Portal user can choose to show only parent entities (with configuration)
• Added the ability to allow RegMol users with Manager privilege to edit an entity registered by another user

Scilligence Corporation, the leading provider of a unified informatics platform for small molecules and biologics, has attained ISO 27001 certification, marking a significant milestone in our commitment to information security. Certification was achieved after the successful completion of an 8-month audit.

ISO 27001 is the accepted global benchmark for demonstrating your information security management system (ISMS). This accreditation ensures that we comply with the best practices in information technology and demonstrates our ongoing efforts toward maintaining information security.

At Scilligence, we understand the paramount importance of data security in today's digital landscape. Our commitment to obtaining and maintaining ISO 27001 certification reflects our unwavering dedication to prioritizing the confidentiality, integrity, and availability of our customers' data.

About Scilligence

We provide a versatile and tailored scientific informatics platform designed to foster collaboration, boost productivity, facilitate data-driven decision-making, and ensure robust compliance and data security. Through the utilization of our integrated toolset, organizations can optimize their R&D workflows, expedite innovation, and propel scientific discoveries forward.

Scilligence offers a suite of premium products to cater to your specific requirements:

• Scilligence ELN: A Cross-Platform Electronic Lab Notebook for Chemistry and Biology
• Scilligence RegMol: A Cross-Platform Registration & Assay Database for Biologics, Small Molecules, and Conjugates such as ADCs
• Scilligence Inventory: A Cross-Platform Inventory System for Life Science R&D
• Scilligence PMF: A Project, Workflow, and Customer-Relationship Management System for Life Science R&D
• Scilligence SDMS: A Cross-Platform Scientific Data Management System
• TouchMol4Office: A tool that empowers Cheminformatics and Bioinformatics within Microsoft Office, seamlessly integrating informatics into your daily operations

UI/UX Improvements

• Improvements to drawing editor icon display
• Added tool tips to peptide enumeration function for improved usability

Assay Protocols and Views

• Assay Views: Improvements to result sorting order and consistency in downloads
• Added Assay view ability to show residual standard deviation (RSD %) values alongside average of IC50 assay results
• Added Assay Protocol ability to show other values of Inhibitory Concentration (IC) along with IC50 in the same assay protocol
• Assay Protocol: Added Next and Previous buttons to improve navigating between individual data results

Cross-Application Integration

• Improvements to database data storage and access for data push from ELN to RegMol
• Improvements to database data storage and access for data pull from RegMol to Focus

Registration Improvements

• On parent and batch registration pages, added configuration options for hiding and adding features
• Improvements to Parent attachment table data capture and storage
• Improvements to the default uniqueness check for entities with form types that do not use a drawing editor
• Improvements in audit trail information capture in entity history
• Improvements to the data capture and display for SDF file entity headers when downloaded to SDF file
• Improvements to information message error notification when registering an entity batch to a different entity type than the existing parent, the message will include the existing parent type and ID
• Added rule for stripping solvates for entity registration and bulk upload
• Added check parent function for protein sequence in bulk register
• Information message improvements when inadvertently mapping the same field twice in bulk upload
• Added feature to allow a user other than owner or admin to edit an entity batch
• Improvements to parent synonym data capture using bulk update
• Added feature to allow an entity registered from ELN to be edited in RegMol by any coauthor of the ELN experiment
• Improvements to information message during bulk register mapping if two columns are being mapped to the same field in error
• Added ability for a zero solvate ratio for capturing trace or unknown amounts of solvate
• Improvements to process for adding custom fields

Search and Explorer

• Added display of Parent Name to the Parent Explorer page
• Improved usability in advanced search results where hovering over entity type icon will display the name of the entity
• Improved search performance by allowing exact match for parent or entity ID
• Improved stereochemistry structure search by using Cahn–Ingold–Prelog (CIP) priority system designations